What Are The Most Addictive Prescription Drugs?

In December 27, 2021
Addiction to opioids
Addiction to opioids

What Are The Most Addictive Prescription Drugs?

Misuse of addictive prescription drugs is on the rise, and the numbers are higher now than ever. Addiction to opioids knows no bounds: You can become addicted to opioids even through a legitimate prescription from a doctor. Opioid addiction can take hold quickly, making it essential to know the most addictive prescription drugs. Keep reading to learn more about the most addictive prescription drugs that run the highest risk of a severe addiction to opioids.


Vicodin, also known as Hydrocodone, is a highly addictive prescription medication. According to the National Library of Medicine, Vicodin is in a class of drugs called opiate (narcotic) analgesics and in a class of medications called antitussives. Hydrocodone relieves pain by changing how the brain and nervous system respond to pain. Hydrocodone relieves cough by decreasing activity in the part of the brain that causes coughing.

Side effects include:

  • Constipation
  • Drowsiness
  • Lightheadedness
  • Fuzzy thinking
  • Anxiety
  • Abnormally happy or abnormally sad mood
  • Dry throat
  • Difficulty urinating
  • Rash
  • Itching
  • Narrowing of the pupils (black circles in the center of the eyes)
  • Slowed or irregular breathing
  • Agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
  • Nausea, vomiting, loss of appetite, weakness, or dizziness
  • Inability to get or keep an erection
  • Irregular menstruation
  • Decreased sexual desire
  • Chest tightness


According to the FDA, OxyContin is a strong prescription pain medicine that contains an opioid (narcotic) that is used to manage pain severe enough to require daily around-the-clock, long-term treatment with an opioid, when other pain treatments such as non-opioid pain medicines or immediate-release opioid medicines do not treat your pain well enough, or you cannot tolerate them. It is a long-acting (extended-release) opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and addiction to opioids that can lead to death.

Side effects of OxyContin include:

  • Constipation
  • Nausea
  • Sleepiness
  • Vomiting
  • Tiredness
  • Headache
  • Dizziness
  • Abdominal pain
  • Trouble breathing
  • Shortness of breath
  • Fast heartbeat
  • Chest pain
  • Swelling of your face, tongue, or throat
  • Extreme drowsiness
  • Light-headedness when changing positions
  • Feeling faint


Percocet, also known as Oxycodone, is used to relieve moderate to severe pain, according to the National Library of Medicine. Oxycodone extended-release tablets and extended-release capsules are used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medicines.

Oxycodone extended-release tablets and extended-release capsules should not be used to treat pain that can be controlled by medication taken as needed. Oxycodone extended-release tablets, extended-release capsules, and concentrated solutions should only be used to treat people who are tolerant (used to the effects of the medication) to opioid prescriptions because they have taken this type of medication for at least one week. Oxycodone is in a class of drugs called opiate (narcotic) analgesics. It works by changing how the brain and nervous system respond to pain.


Ambien is a prescription medicine for the short-term treatment of adults who have trouble falling asleep. It is a powerful sedative to treat severe insomnia that can lead to severe side effects, addiction, and overdose. It is not meant to be used in the long-term for these reasons.

Some of the severe side effects that Ambien may cause include:

  • Getting out of bed while not being fully awake and doing an activity that you do not know you are doing.
  • Abnormal thoughts and behavior. For Ambien and Ambien CR, symptoms include more outgoing or aggressive behavior than usual, confusion, agitation, hallucinations, worsening of depression, and suicidal thoughts or actions, and additionally, for Ambien CR, acting strangely.
  • Memory loss
  • Anxiety
  • Severe allergic reactions. Symptoms include swelling of the tongue or throat and trouble breathing. Get emergency medical help if you get these symptoms after taking Ambien or Ambien CR.

Getting Treatment for Addiction to Opioids at Seasons in Malibu

Opioids are a very dangerous class of drugs that can take hold of the brain and make it very difficult to let go of. Opioid addiction quickly leads to overdose and death, and misuse is rising. Some of the most addictive prescription drugs include Vicodin, OxyContin, Percocet, and Ambien. However, there are many more that can lead to addiction to opioids. If you or someone you love has developed an addiction to opioids, Seasons in Malibu can help you. Through medication-assisted detox, individualized treatment, holistic therapies, and an individualized aftercare plan, our luxury drug rehab will give you the best possible chances for long-term success.

Treatment at Seasons in Malibu is systemic, integrative, and client-centered. Our counselors are invested in your well-being and are ready around the clock to guide you or a trusted friend or family member through the initial steps of overcoming drug or alcohol addiction.

Our superior team of clinicians can pinpoint areas of focus that will give the client the most advanced opportunity for success. Our approach towards healing is collaborative, comprehensive, and committed, as well as individually tailored to your specific needs.

For more information, visit seasonsmalibu.com.

By Jaclyn Uloth


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